A remote-controlled Israeli assassination drone fired a missile at an unidentified man riding a motorcycle in the northern town of Jabaliya on Saturday, killing him on the spot.
Another man was mortally wounded in the attack. He was rushed to a nearby hospital, where he succumbed to his injuries.
Following the deadly strike, another Israeli military aircraft struck a target in the Zeitoun district of southern Gaza City.
Four people, including a child, were injured in the attack, and scores of women and children went into a state of shock.
Early on Saturday morning, Israeli fighter jets targeted three sites in northern and central areas of the Gaza Strip. However, there were no reports of casualties.
On Thursday, Israel carried out an airstrike on a neighborhood in the northern Gaza Strip.
The target was a security facility of the Palestinian resistance movement Hamas.
Gaza has been blockaded since 2007, a situation that has caused a decline in the standard of living, unprecedented levels of unemployment, and unrelenting poverty.
The apartheid regime of Israel denies about 1.7 million people in Gaza their basic rights, such as freedom of movement, jobs that pay proper wages, and adequate healthcare and education.